Hermann is a city designated in 1842 as the county seat of Gasconade County , Missouri , United States . It is near the center of the Missouri Rhineland and south of the Missouri River . The population was 2,431 at the 2010 census .
The Hermann AVA is an American Viticultural Area located in Gasconade County , Missouri , and entirely contained within the larger Ozark Mountain AVA . The wine appellation is located on the southern side of the Missouri River near the town of Hermann , about halfway between St. Louis and Jefferson City . The AVA covers the northern-most hills of the Ozark Plateau with many of the 200 acres (80 hectares) of vineyards planted along hillside locations. As of 2007, seven wineries were producing wine in appellation, including Missouri's largest winery, Stone Hill Winery .